BXRC Center

Biomolecular X-Ray Crystallography Center




Yang, C., Curth, U., Urbanke, K. & Kang, C. (1997) Crystal Structure of Human Mitochondrial Single-Stranded DNA Binding Protein at 2.4 Resolution. Nature Structural Biology. 4, 153-157.

Webster, G., Genschel, J., Curth, U., Urbanke, C., Kang, C. & Hilgenfeld, R. (1997) Common Core for Binding Single-Stranded DNA: Structural Comparison of the Single-Stranded DNA-binding Proteins (SSB) from E. coli and Human Mitochondria. FEBS Letters 411, 313-316

Wang, S., Trumble, B., Liao, H., Dunker, K.,& Kang, C. (1998) Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum. Nature Structural Biology 5, 476-483.

Liu, C., Pasa-Tolic, L, Hofstadler, S., Kang, C., Harms, A., Sinha, N., Smith, R. (1998) Probing RegA-RNA Interactions Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Analytical Biochemistry 262, 67-76.

Weil, J., Min, T., Wang, S., Yang, C., Sinha, N., Kang, C. (1998) Stabilization of the i-motif by Novel Intramolecular Adenine.Adenine.Thymine Base Triad in the Crystal Structure of d(ACCCT). Acta Crystallographica. D55, 422-429.html

Eidness, M.K., Burden, A.E., Richie, K.A., Kurtz, D.M., Scott, R.A., Smith, E.T., Beard, B., Min, T., Kang, C. (1999) Modulation of the Redox Potential of the Fe(SCys)4 Site in Rubredoxin by the Orientation of a Peptide Dipole (1999) Biochemistry 38, 14803-14809.pdf

Kang, C. And Dunker, A.K. Calsequestrin Structure and Function (2001), in: Methods in Molecular Biology: Calcium Binding Proteins, ed. By H.J. Vogel.

Min, T., Ergenecan, C., Eidness, M.K., Ichiye, T. & Kang, C. (2001) Leucine 41 is a Gate for Water Entry in the Reduction of Clostridium pasteurianum Rubredoxin Protein Science 10, 613-621.pdf

Dunker,A.K, Kang,C. et.al. (2001) Intrinsically disordered protein. J. Mol. Graphics. Modeling 19, 26-59.

Higgs,P., Letain,T.E. Merriam,K.K., Burke,N.S., Park,H., Kang,C., Postle,K. (2002) TonB Interacts with Non-receptor Proteins at the Outer Membrane of Escherichia coli J.Bacteriology. 184, 1640-1648.pdf

Park,H-J., Yang,C., Treff,N., Satterlee,J. & Kang.C. (2002) Crystal Structures of Components III and IV Glycera dibranchiata Monomeric deoxy- and cyano-Hemoglobin. PROTEINS: Structure, Function and Genetics 49, 49-60.pdf

Min,T., Eidsness,M.K., Ichiye,T. & Kang, C. (2001) Regulation Mechanism of Redox Reaction in Rubredoxin. J. Microbiology 39, 149-153.

MacLennan, D.H. and Kang, C. (2002) Review: Structure-Function Relationships in Ca2+ Cycling proteins. Journal of Molecular and Cellular Cardiology. 34, 1-22.html

Park,H-J., Suquet,C., Savenkova, M.I., Satterlee,J.D & Kang,C. (2002) Crystallization and Preliminary X-ray Analysis of the DOS Heme Domain: A new Heme Oxygen Sensor in E. coli. Acta Crystallographica D.58, 1504-1506.html

Park,H-J., Zhang K., Ren,Y, Sinha, N., Taylor, J-S. & Kang,C. (2002) Crystal Structure of a DNA Decamer Containing cis-syn Thymine dimer. PNAS, 99:15965-15970.pdf

Park,H-J., Wu,S., Dunker,A.K. & Kang,C. (2003) Polymerization of Calsequestrin: Implications for Ca2+ Regulation. J.Biol.Chem 278, 161176-16182.pdf

Min,T., Kasahara,T., Bedgar,D.L., Youn,B., Lawrence,P.K., Gang,D.R., Halls,S.C., Park,H-J., Jacqueline,L. Hilsenbeck,J.L., Davin,L.B., Lewis,N.G. & Kang,C. (2003) Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases, and their relationship to isoflavone reductases. J.Biol.Chem 278, 50714-50723.

Ergenekan, KE, Thomas, D, Fischer, JT, Tan, M-L, Eidsness, MK, Kang, C, and Ichiye,T. (2003) Prediction of Reduction Potential Changes in Rubredoxin: A Molecular Mechanics Approach. Biophysical Journal 85:2818-2829.

Kang,C. (2003) Calsequestrin, Handbook of Metalloproteins series. Vol III, Wiley.

Hilsenbeck, J.L., Park, H-J., Chen, G., Youn, B., Postle, K. & Kang, C. (2004) Crystal Structure of the Cytotoxic Bacterial Protein Colicin B at 2.5 Resolution: J. Molecular Microbiology 51, 711-720.

Kim, S-J., Kim, M-R, Bedgar, D.L., Moinuddin, S.G.A., Cardenas, C.L., Davin, L.B., Kang, C. & Lewis, N.G. (2004) Functional Reclassification of the Putative Cinnamyl Alcohol Dehydrogenase (CAD) Multigene Family in Arabidopsis. PNAS 101, 1455-1460.

Park, H-J., Hilsenbeck, J.L., Kim, H.J., Shuttleworth, W.A., Evans, J.N. & Kang, C. (2004) Structural Studies of Streptococcus pneumoniae EPSP Synthase in Unliganded State, Tetrahedral intermediate Bound State and S3P-GLP Bound State. J. Molecular Microbiology 51, 963-971.

Park, H-J., Suquet, C., Satterlee, J.D. & Kang, C. (2004) Insights Into Signal Transduction Involving PAS Domain Oxygen Sensing Heme Proteins from the X-ray Crystal Structure of E. coli Dos Heme Domain (EcDosH) Biochemistry. 16, 2738-2746.
Venclovas,C., Ginalski,K. & Kang, C. Sequence-structure mapping errors in the PDB: OB-fold domains (2004) Protein Science 13, 1594-1602.

Park, H-J., Park, I-Y., , Kim EJ, Wu, S., Youn, B., Fields, K., Dunker, A.K., & Kang, C. (2004) Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization. J.Biol.Chem.. 297, 18026-18033.

Park, IY., Youn, B., Harley, JL., Eidness, MK., Smith, E., Ichiye, T. & Kang, C(2004) The unique hydrogen bonded water in the reduced form of Clostridium pasteurianum rubredoxin and its possible role in electron transfer. J.Biol.Inor.Chem. 9. 423-428.
Park, IY, Eidness, MK, Lin, IJ., Gebel, EB., Youn, B., Harley, JL, Machonkin, TE., Frederick, RO., Markley, JL., Eugene Smith, E., Ichiye, T. & Kang,C. (2004) Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin. PROTEINS: Structure, Function and Genetics 57, 618-624.

Rogers, SW, Youn, B, Rogers, JC, & Kang,C. (2004) Purification, Crystallization and Preliminary Crystallographic Studies of the Ligand Binding Domain of a Plant Vacuolar Sorting Receptor. Acta Crystallographica D6 2028-2030.
Park, IY, Kim, E-J, Park, HJ, Fields, K., Dunker, KA., & Kang, C. (2005) Interaction Between Cardiac Calsequestrin and Drugs with Known Cardiotoxicity, J. Mol. Pharmacology 67, 95-105.

Youn, B, Moinuldin, GAS, Davin, LB, Lewis, NG & Kang, C. (2005) Crystal structures of apo-form, binary and ternary complexes of Podophyllum secoisolariciresinol dehydrogenase (SDH) J.Biol.Chem. 280, 12917-26.
Tan, M-L, Kang C & Ichiye, T. (2006) The role of backbone stability near Ala44 in the high reduction potential class of rubredoxins PROTEINS: Structure, Function and Genetics (in press)62, 708-714.

Kim, EJ, Tam, M, Siems, WF. & Kang C. (2005) Effects of the drugs with muscle-related side effects and affinity to calsequestrin on the calcium regulatory function of SR microsomes. J. Mol. Pharmacology 68(6): 1708-15.
Lee, S.M., Youn, B.H., Kim, C.S., Kim, J.S., Kang C., and Kim, J. (2006) g-irradiation and doxorubicin in normal human cells show cell cycle arrest via different pathways. Mol. Cell. 20, 331-338.

Moinuddin, SGA, Youn, B, Bedgar, DA, Costa, MA, Helms, G, Kang, C, Davin L, & Lewis, NG (2006) Secoisolariciresinol Dehydrogenase: Mode of Catalysis and Stereospecificity of Hydride Transfer in Podophyllum peltatum, Org. Biomol Chem. 4, 808-816.

Youn, B., Camacho, R., Moinuddin, SGA, Lee, C., Davin, LB, Lewis, NG & Kang, C. (2006) Crystal structures and catalytic mechanisms of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4. Org. Biomol. Chem. 7, 1687-1697.
Hyatt DC, Youn, B, Zhao Y, Santhamma B, Coates RM, Croteau R. & Kang, C. (2007) Structure of limonene synthase, a simple model for terpenoid cyclase catalysis PNAS 104, 5360-5365.

Cho MH, Corea OR, Yang H, Bedgar DL, Laskar DD, Anterola AM, Moog-Anterola FA, Hood RL, Kohalmi SE, Bernards MA, Kang C, Davin LB, Lewis NG. (2007) Phenylalanine biosynthesis in Arabidopsis thaliana: Identification and characterization of arogenate dehydratases. J Biol Chem. 282, 30827-35.

Kim EJ, Youn B, Kemper L, Campbell C, Milting H, Varsanyi M & Kang C (2007) Biochemical analysis of human cardiac calsequestrin and its deleterious mutants. J Mol Biol. 373, 1047-57.

Muir, T., Wilson-Rawls, J., Stevens, J., Rawls, A., Kang, C. & Skinner, MK. (2008) Integration of CREB and bHLH transcriptional pathways through heterodimerization of the proteins. Molecular Reproduction and Development 75, 1637-1652.
Nissen M, Youn, B, Knowles D, Ballinger J, Belchik S, Xun L and Kang C (2008) Crystal structures of NADH:FMN oxidoreductase (EmoB) at different stages of catalysis. J Biol. Chem. 283, 28710-28720.

Nissen M, Kumar M, Youn B, Knowles DB, Lam KS, Ballinger WJ, Knowles NR and Kang C. (2009) Characterization of Potato Multicystatin and its Structural comparison with other Cystatins, Plant Cell 21, 861-875. doi:

Ahn JH, Kim Y-J, Kim T, Song H-G, Kang C & Ka, JO (2009) Quantitative improvement of 16S rDNA DGGE analysis for soil bacterial community using real-time PCR. Journal of Microbiological Methods 78, 216-222.

Saballos A, Ejeta G, Sanchez E, Kang C, and Vermerris W (2009) A genome-wide analysis of the cinnamyl alcohol dehydrogenase family in sorghum (Sorghum bicolor (L.) Moench) identifies SbCAD2 as the Brown midrib6 gene. Genetics. 181, 783-795.

Webb, BN, Ballinger JW, Kim E, Belchik S, Lam KS, Youn B, Nissen M, Xun L, and Kang C (2010) Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) OF Burkholderia cepacia AC1100. J Biol. Chem. 285, 2014-2027. doi: jbc

Xun, L, Belchik, SM, Xun, R, Huang, Y, Zhou, H, Sanchez, E, Kang, C and Board, PP. (2010) S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases in bacteria and fungi. Biochemical Journal 428, 419-427.

Kang, C, Nissen, M, Sanchez, E and Milting, H. (2010) Potential adverse interaction of human cardiac calsequestrin. European Journal of Pharmacology 646, 12-21. doi: EJP

Sellhorn G, Youn B, Webb BN, Gloss LM, Kang C, and Grimes HD (2011) Biochemical characterization, kinetic analysis and molecular modeling of recombinant vegetative lipoxygenases from soybean. International Journal of Biology, 3 (1). doi: IJB

Sanchez EJ, Munske G, Criswell A, Milting H, Dunker AK and Kang CH (2011) Phosphorylation of human calsequestrin: implications for calcium regulation. Molecular and Cellular Biochemistry 353, 195-204. doi: MCB

Wang W, Perovicc I, Chittularud J, Kaganoviche A, Nguyena LT, Liaoa J, Auclairf JR, Johnsona D, Landerua A, Simorellisc AK, Juc S, Cooksone MR, Asturiasd FJ, Agarf JN, Webb BN, Kang C, Ringec D, Petskoc G, Pochapskyc, TC & Hoanga, QQ. (2011) Soluble _-synuclein construct forms a dynamic tetramer. PNAS 108, 17797-17802.

Kang C, Hayes R, Sanchez EJ, Webb BN, Li Q, Hooper T, Nissen MS & Xun L. (2012) Furfural reduction mechanism of a zinc-dependent dehydrogenase from Cupriavidus necator JMP134. J. Molecular Microbiology 83, 85-95 doi: JMM

Lee KW, Maeng J, Choi JY, Lee YR, Hwang CY, Park SS, Park HK, Chung BH, Lee S, Kim Y, Jeon H, Eom SH, Kang C, Kim DH, Kwon K-S (2012) The role of junctin interactions in cellular dynamics of the calsequestrin polymer upon calcium J Biol. Chem. 287, 1679-1687

Sanchez EJ, Lewis KM, Munske GR, Nissen MS & Kang C. (2012) Glycosylation of Skeletal calsequestrin, Implications for its function. J Biol. Chem. 287, 3042-3050. doi: jbc

Sanchez EJ*, Lewis KM*, Danna BR, Kang C. (2012) High-Capacity Ca2+-binding of human skeletal calsequestrin J Biol. Chem. 287, 11592-11601. doi: jbc

Saballos A, Sattler SE, Sanchez EJ, Foster TP, Xin Z, Kang C, Pedersen JF, Vermerris W. (2012) Brown midrib2 (Bmr2) encodes the major 4-coumarate:Coenzyme A ligase involved in lignin biosynthesis in sorghum (Sorghum bicolor (L.) Moench). The Plant Journal 70, 818-830. doi: Plant

Hayes RP, Webb BN, Subramanian AK, Nissen M, Popchock A, Xun L and Kang C. (2012) Structural and catalytic differences between two FADH2-dependent monooxygenases: TftD from Burkholderia cepacia AC1100 and TcpA from Cupriavidus necator JMP134. Int. J. Mol. Sci. 13, 9769-9784. doi:10.3390/ijms13089767

Green AR, Hayes RP, Xun L & Kang, C. (2012) Structural Understandingof GSH-dependent Reduction Mechanism of Glutathionyl-Hydroquinone Reductases. J Biol. Chem. 287 doi:

Subramania AK, Nissen MS, Lewis KM, Muralidharan AK, Sanchez EJ, Milting H, Kang C. (2012) Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential inhibition by Caffeine and Gallocatecin. Int. J. Mol. Sci. 13, 14326-14343. doi: ijms-23206

Hayes R, Green A, Nissen M, Lewis K, Xun L, and Kang C. (2013) Structural Characterization of 2,6-Dichloro-p-hydroquinone 1,2-Dioxygenase (PcpA) from Sphingobium chlorophenolicum, a New Type of Aromatic Ring-cleavage Enzyme. Mol Microbiology 88, 523-536. Vol 88 issue 3

Walker AM, AHayes RP, Youn B, Vermerris W, Sattler SE and Kang C. (2013) Elucidation of the structure and reaction mechanism of Sorghum bicolor hydroxycinnamoyltransferase and its structural relationship to other CoA-dependent transferases and reductases. Plant Physiology 162, 640-651. Plant Physiology 162

Wei Z, Sun K, Sandoval FJ, Cross JM, Christine Gordon C, Kang C, and Roje S. (2013) Folate Polyglutamylation Stabilizes the Activity State of Mitochondrial Serine Hydroxymethyltransferases from Arabidopsis thaliana. Arch Biochem Biophys 536, 87-96.

Sanchez EJ, Hayes RP, Barr JT, Lewis KM, Webb BN, Subramanian AK, Nissen MS, Jones JP, Shelden EA, Sorg BA, Fill M, Schenk JO and Kang C. (2013) Potential Role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine. Drug and Alcohol Dependence 133, 344-351. DAD 133

Hayes RP, Lewis KM, Xun L and Kang C (2013) Catalytic mechanism of 5-chlorohydroxyhydroquinone dehydrochlorinase from the YCII superfamily of largely unknown function. J Biol. Chem. 288, 28447-28456. JBC 288:

Green, AR, Nissen MS, Kumar, GNM, Knowles NR and Kang C (2013) Characterization of Solanum tuberosum Multicystatin and the Significance of Core Domains. Plant Cell 25, 5033-5066. Plant Cell 25

Green AR, Lewis KM, Barr JT, Jones JP, Lu F, Ralph J, Vermerris W, Sattler SE and Kang C. (2014) Determination of the structure and catalytic mechanism of Sorghum bicolor caffeic acid O-methyltransferase and the structural impact of three brown midrib12 mutations. Plant Physiology 165, 1440-1456. (Plant Phys 165)

Babb EM, Kang C, Brinkman MA and Lee C (2014) Argentine Worker Ant (Hymenoptera: Formicidae) Mortality Response to Sodium Salicylate and Sodium Cinnamate. J. Entomol. Sci. 49, 1-10.

Hayes RP, Moural TW, Lewis KM, Onofrei D, Xun L and Kang C (2014) Structures of the inducer-binding domain of pentachlorophenol-degrading gene regulator PcpR from Sphingobium chlorophenolicum. Int. J. Mol. Sci. 15, 20736-20752. IJMS 15

Cakir B, Tuncel A, Green AR, Koper K, Hwang S-K, Okita TW and Kang C (2015) Substrate binding properties of ADP-glucose pyrophosphorylase determined by using isothermal titration calorimetry. FEBS Letters 589, 1444-1449. doi:10.1016/j.feblet.2015.04.042

Youn H, Son B, Kim W, Jun SY, Lee JS, Lee JM, Kang C, Kim J and Youn B (2015) Dissociation of MIF-rpS3 Complex and Sequential NF-κB Activation Is Involved in IR-Induced Metastatic Conversion of NSCLC. J Cell Biochem , 116, 2504-2016.

Sattler SA, Wang X, Lewis KM, DeHan PJ, Park CM, Xin Y, Liu H, Xian M, Xun L and Kang C. (2015) Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily. JBC 290. 18914-18923. doi: 10.1074/jbc.M115.652537.

Kim W, Kim EG, Yang HJ, Kwon TW, Han SY, Lee S, Youn, HS, Jung Y, Kang C and Youn BH (2015) Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing. Experimental Dermatology 24, 611-617. doi: 10.1111/exd.12735.

Lewis K, Ronish LA, Rios E and Kang C (2015) Characterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregates Myopathy. JBC 290, 28665-28674. doi: 10.1074/jbc.M115.686261

Atabaev TS, Lee JH, Han D-W, Choo KS, Jeon UB, Hwang JY, Yeom, JA, Kang C, Kim H-K and Hwang, YH (2016) Multicolor nanoprobes based on silica-coated gadolinium oxide nanoparticles with highly reduced toxicity. RSC Adv. 6, 19758-19762. doi: 10.1039/C5RA27685C

Springer A, Kang C, Rustgic S, Wettstein D, Reinbothe C, Pollmann S, and Reinbothe S. (2016) Programmed chloroplast destruction during leaf senescence Q:4; 5 involves 13-lipoxygenase (13-LOX). PNAS. 113, 3383-3388. pii: 201525747. [Epub ahead of print]

Jun S-Y, Lewis KM, Youn B, Xun L and Kang C (2016). Structural and Biochemical Characterization of EDTA Monooxygenase and its Physical Interaction with a Partner Flavin Reductase. Mol Microbiol. 100(6): 989-1003. doi:10.1111/mmi.13363. Epub 2016 Apr 13.

Son B, Jun SY, Seo H, Youn H, Yang HJ, Kim W, Kim HK, Kang C, Youn B (2016) Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer. Sci Rep. 6. 21986 doi:10.1038/srep21986.

Walker AM, Sattler SA, Regner M, Jones JP, Ralph J, Vermerris W, Sattler SE and Kang C (2016). The structure and catalytic mechanism of Sorghum bicolor caffeoyl-CoA O-methyltransferase. Plant Physiology 171 doi:10.1104/pp.16.00845.

Lewis KM, Munske GR, Byrd SS, Kang J,Cho HJ, Rios E and Kang C (2016) Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle. Int. J. Mol. Sci. 17, 1539. doi:10.3390/ijms17091539

Mourals TM, Lewis KM, Barnaba C, Zhu F, Palmer NA, Sarath G,Scully ED, Jones JP, Sattler SE, Kang C (2017) Characterization of class III peroxidases from switchgrass (Panicum virgatum) Plant Physiology 173(1):417-433 doi:10.1104

Sattler SA, Walker AM, Vermeriss W, Sattler SE and Kang C (2017) Structural and Biochemical Characterization of Cinnamoyl-CoA Reductases from Sorghum bicolor. Plant Physiology 173 (2): 1013-1044. doi:10.1104/pp.16.01671

Manno C, Figueroa L, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C and Rios E (2017) Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle. Proc. Natl. Acad. Sci. USA 114. E638-E647.

Dodgen C, Uzezi V, Kang C and Lee C (2017) Exploring the Use of Free Bioinformatics Modules in an Introductory Biochemistry Course. Georgia Journal of Science 75, 2

Jun SY, Walker AM, Kim H, Ralph J, Vermerris W, Sattler SE and Kang C (2017) The enzyme activity and substrate specificity of two major cinnamyl alcohol dehydrogenases in sorghum (Sorghum bicolor (L.) Moench), SbCAD2 and SbCAD4. Plant Physiology 174(4): 2128-2145 DOI: https://doi.org/10.1104/pp.17.00576

Jun SY, Sattler SA, Cortez GS, Vermerris W, Sattler SE and Kang C (2018) Biochemical analysis of substrate specificity of Sorghum bicolor phenylalanine ammonia-lyase (PAL). Plant Physiology 176: 1452-1468. doi: 10.1104/pp.17.01608.

Lee JH, Lewis KM, Moural TW, Kirilenko B, Borgonovo B, Prange G, Koessl M, Huggenberger S, Kang C and Hiller M (2018) Molecular parallelism in fast-twitch muscle proteins in echolocating mammals. Science Advances doi: https://doi.org/10.1101/244566.

Lewis KM, Sattler SA, Kang CH, Wu HM, Kim SG and Kim HB (2018) Characterization of anti-inflammatory effect of soybean septapeptide and its molecular mechanism. Korean J. Microbiology. DOI https://doi.org/10.7845/kjm.2018.8041

Ly T, Krieger I, Tolkachev D, Krone C, Moural T, Samatey FA, Kang C, Kostyukova AS (2018) Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H. Protein Sciences 27, 498-508. DOI:10.1002/pro.3341.

BXRC, Fulmer 264, Washington State University, Pullman WA 99164, 509-335-1523, Contact Us